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Making the connection: gut dysbiosis, allergy and synbiotics

A deeper understanding of role of the gut microbiome in health and disease is changing how we think about and treat cows’ milk protein allergy (CMPA).

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Clinical benefits of SYNEO™ | Paediatrics Healthcare

Clinical benefits of SYNEO™

SYNEO™ is the only CMPA range to contain a unique, patented blend of pre- and probiotics, inspired by components of breast milk, that work together to help promote a healthy gut microbiota and support immune system development.14–17

In clinical trials involving infants with CMPA, addition of SYNEO™ demonstrated:13–16,18,19

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Rebalancing of the gut microbiota closer to healthy breastfed infants

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Fewer reports of infections and antibiotic use

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Fewer reports of asthma-like symptoms and need for asthma medicine after 1 year

Discover how the SYNEO™ range could make a difference to your patients with CMPA

Neocate Syneo

Neocate® SYNEO™

A nutritionally complete, amino acid based, powdered infant formula for special dietary use, with a unique blend of ingredients including short- and long-chain FOS (fructo-oligosaccharides) and Bifidobacterium breve M16V. Available on PBS.

Aptamil® AllerPro Syneo™ - From Birth to 6 Months | Paediatrics Healthcare

Aptamil® AllerPro SYNEO™ Infant Formula (0-6 months)

A nutritionally complete, premium extensively hydrolysed formula (eHF) for infants from birth (0–6 months) with confirmed mild to moderate cows’ milk (not anaphylaxis) and/or soy protein allergy, requiring a partial or complete breast milk substitute.

Neocate Syneo

Aptamil® AllerPro SYNEO™ 2 (6-12 months)

A premium extensively hydrolysed formula (eHF) for infants with confirmed mild to moderate cows’ milk (not anaphylaxis) and/or soy protein allergy, requiring a partial or complete breast milk substitute as part of a mixed diet.

References:

1. Vighi G et al. Clin Exp Immunol. 2008;153(Suppl 1):3–6.

2. Azad M et al. Clin Exp Allergy 2015;45:632–43.

3. Kirjavainen P et al. Gut 2002;51:51–5.

4. Mitsuoka T. Biosci Microbiota Food Health 2014;33:99–116.

5. Roger LC et al. Microbiology 2010;156:3329–41.

6. Abrahamsson TR et al. J Allergy Clin Immunol 2012;129:434–40.

7. Harvey BM et al. Pediatr Res 2014;75:343–51.

8. Candy DCA et al. Pediatr Res 2018;83:677–86.

9. West CE et al. J Allergy Clin lmmunol 2015;135:3–1.

10. Kim BJ et al. Allergy Asthma lmmunol Res 2014;6:389–400.

11. Azad MD et al. BJOG 2016;123:983-93.

12. Sackesen C et al. Front Pediatr 2019;7:372.

13. Van der Aa LB et al. Clin Exp Allergy 2010;40:795–804.

14. Fox AT et al. Clin Transl Allergy 2019;9:5.

15. Jeurink PV et al. Benef Microbes 2013;4:17–30.

16. Scholtens PAMJ et al. J. Annu Rev Food Sci Technol 2012;3:425–447.

17. Martin R et al. Benef Microbes 2010;1(4)367–82.

18. Burks A et al. Pediatr Allergy lmmunol 2015;26:316-22.

19. Chatchatee P et al. J Allergy Clin Immunol 2021; doi; 10.1016/j.jaci.2021.06.025 [Epub ahead of print].

 

 

 Nutricia products are intended for the nutritional management of diseases and related medical conditions and therefore should be used under medical supervision.

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